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    Bioinformatics / Neuroinformatics
    This module is a computer-based introduction to bioinformatics resources.  This easy-to-adopt module weaves together several important bioinformatic tools so students can grasp how each is used in...

    Keywords: bioinformaticsNIBLSEImageJquantitative trait locusQTL

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    ABO Blood Group Frequencies
    An Excel workbook in which students can calculate blood type frequencies through different approaches (Hardy-Weinberg, quadratic formula, and the EM algorithm). The workbook shows the formulas...

    Keywords: Hardy-WeinbergExcelResources @ ESTEEMblood type frequencies

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    Using computational molecular modeling software to demonstrate how DNA mutations cause phenotypes
    This lesson is a five-week series of laboratory activities designed to help students transition from applying lower order thinking skills to the central dogma to applying higher-order thinking skills.

    Keywords: bioinformaticsNIBLSEProtein StructureDNAmolecular modelinggenotypephenotypeCourseSourcecomputational modelingcentral dogmaplant leaf structure

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    Module 6: Alternative Splicing
    This module explores how multiple different mRNAs and polypeptides can be encoded by the same gene. After completing this module students will be able to explain how alternative splicing of a gene...

    Keywords: geneticsdata visualizationmolecular biologygenomicsexonintronalternative splicingSimilarity searchesMessenger RNA

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    What the Mendel
    Students practice hypothesis testing using Mendelian genetics for monohybrid and dihybrid crosses. Both corn and Wisconsin Fast Plants are employed.

    Keywords: geneticsplantsmendelian inheritancephenotypecotelydoncornWisconsin fast plants

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    Allele and Phenotype Frequencies in Rock Pocket Mouse Populations
    A lesson that uses real rock pocket mouse data collected by Dr. Michael Nachman and his colleagues to illustrate the Hardy-Weinberg principle.

    Keywords: EvolutionResources @ HHMI - BioInteractiveNatural SelectionScientific ProcessStatistics and Mathevolution of populations

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    Behavioral Genetics: Investigating the genes of a complex phenotype in fruit flies
    Introductory genetics laboratory published as GSA Learning Resource

    Keywords: behaviorbioinformaticsNIBLSEdrosophilagenetic basisfruit fliesmodel organism

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    The Evolution of Color Vision in Monkeys: From Nucleotides to Ecology
    This case study examines the evolution color vision in Old World and New World monkeys from multiple biological perspectives.

    Keywords: phylogeneticsgenescase studybiologyResources @ NSF - NCCSTSColor visiondichromatictrichromaticnucleotidesproteinsopsinscell functioncone cellsphotoreceptorsspectral shiftgene duplicationmeiosissex-linkedfood gatheringmonkeysprimatesResources @ QUBES - Teaching & Referenceundergraduate biology education

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    My Dog IS My Homework: Exploring Canine Genetics to Understand Genotype-Phenotype Relationships
    To facilitate understanding of the fundamental genetic concept of the genotype-phenotype relationship in our introductory biology students, we designed an engaging multi-week series of related...

    Keywords: gel electrophoresissequence analysiscanine geneticsdeoxyribonucleic acid (DNA)dog coat morphologygenotype and phenotypemutationsPolymerase chain reaction (PCR)single nucleotide polymorphism (SNP)

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    Garden peas and cabbage plants: A short 'de-simplified genetics' activity
    Are plants of genotype T/T tall? Are those of genotype t/t short? Let's find out in this short activity entirely based on a segment of: Smith's (2014) "It’s Not Your Grandmother’s Genetics Anymore!"

    Keywords: geneticsintroductory biologyclickersenvironmentplantsin-class activitygenotypephenotypeMendel

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    Exploring the Introduction of Genetic Variation by Random Mutation: Avida-Ed Lab Book Exercise 1
    An introductory activity introducing the role of random mutation in generating genetic variation using the Avida-ED simulation.

    Keywords: geneticsEvolutionavida-edmutationsoftware simulations

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    Building creatures with the central dogma of biology
    Activity that demonstrates how nucleotide changes can affect phenotypes

    Keywords: amino acidsnucleotidesRNADNAgenotypephenotypecentral dogma

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    A Structured Inquiry Approach to Cotyledon Phenotyping
    In this lab, students will work with messy data to try to answer the question “How do plants inherit cotyledon color?”

    Keywords: geneticsplantsphenotypecotelydon

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    How Many More Thymes? A Case of Phytochemical Defense
    National Center for Case Study Teaching in Science- this clicker case addresses several concepts related to the evolutionary ecology of herbivore defenses.

    Keywords: food websgenotypephenotypeHerbivoryherbivoredeterrencemonoterpeneproducerchemotypeThymus vulgaristhymeMediterranean ecosystemchemical defenses

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    Birthday Problem and Class Phenotypic Probabilities
    An Excel workbook exploring two related applications, the Birthday Problem and Class Phenotypic Probabilities. Students enter their own phenotypes into the workbook.

    Keywords: ExcelResources @ ESTEEMphenotypic probabilityallelic frequency

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    A Structured Inquiry Approach to Cotyledon Phenotyping
    In this lab, students will work with messy data to try to answer the question “How do plants inherit cotyledon color?”

    Keywords: geneticsplantsphenotypecotelydon

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    Mol* Adaptation: Case of Severe Insulin Resistance
    This is an adaptation using Mol* on the original case written. This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to...

    Keywords: molecular visualization and analysisPDBMolecular Case Studyinsulin resistanceMol*MolStar

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    A Case of Severe Insulin Resistance
    This case focuses on understanding how a mutation in a cell signalling protein (a kinase) can prevent insulin function and lead to diabetes.

    Keywords: molecular visualization and analysisPDBMolecular Case Studyinsulin resistance

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    How Many More Thymes & Herbivore Defense
    Adaptations to the How Many More Thymes? case study featuring terpene-based herbivore defense and pollinator attraction in Nicotiana plants.

    Keywords: food websgenotypephenotypeHerbivoryherbivoredeterrencemonoterpeneproducerchemotypeThymus vulgaristhymeMediterranean ecosystemchemical defensesManduca sextaNicotiana

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    Regulation of Gene Expression and Adipogenesis by PPAR-γ
    Students learn about transcriptional regulation of PPAR-γ, an important controller of adipose tissue stores and energy metabolism through a drawing/coloring activity of the different components...

    Keywords: gene expressionsmall group worktranscriptional regulationadipose tissuefat metabolismrepressor

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